About In-Path Rules : About packet-mode optimization rules
  
About packet-mode optimization rules
When you create a fixed-target packet-mode optimization rule, you define the inner channel characteristics using these controls: source and destination subnet, source and destination port (or port label), and DSCP marking.
Packet-mode optimization supports these topologies:
Physical in-path
Virtual in-path
WCCP/PBR or TCPv4, UDPv4
PBR for TCPv6, UDPv6
Master and backup
Packet-mode optimization does not support these topologies:
Out-of-path
Serial cluster
Interceptor integration