HTTP optimization works for most HTTP and HTTPS applications, including SAP, customer relationship management, enterprise resource planning, financial, document management, and Intranet portals.

HTTP optimization has been tested on Internet Explorer 6.0 and later and Firefox 2 and later. HTTP optimization has been tested on Apache 1.3, Apache 2.2, Microsoft IIS 5.0, 6.0, 7.5, and 8; Microsoft SharePoint, ASP.net, and Microsoft Internet Security and Acceleration Server (ISA).

FPSE supports SharePoint Office clients 2007 and 2010, installed on Windows 7 (SP1) and Windows 8. SharePoint 2013 does not support FPSE.